Terbutaline Sulfateis the sulfate salt form of terbutaline, an ethanolamine derivative with bronchodilating and tocolyticproperties. Terbutaline sulfate selectively binds to and activates beta-2 adrenergicreceptors, leading to intracellular adenyl cyclase activation via a trimeric Gprotein and subsequent increase in cyclic cAMP production. Increased cAMP levels result in relaxation of bronchial and vascularsmooth muscle mediated through the activation of protein kinase A (PKA), whichphosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration ofintracellular calcium all of which aids the relaxation of airway muscles.Terbutaline sulfate also increases mucociliary clearance and reduces release ofinflammatory cell mediators
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